@article{Aydin_Rencuzogullari_Dalyan_Bayram_Genc_2018, title={The relationship between the variations in Gγ and Aγ promotors and the Hereditary Persistence of Fetal Hemoglobin (HPFH)}, volume={64}, url={https://www.cellmolbiol.org/index.php/CMB/article/view/1838}, DOI={10.14715/cmb/2018.64.1.7}, abstractNote={<p>In the present study, sixty-two samples that have 1.5% and upper level of fetal hemoglobin (HbF), were examined to investigate the relationship between HbF level and non-deletional mutations in both Gγ (G gamma) globin (HBG2) and Aγ (A gamma) globin (HBG1) genes. Four variations were observed in the promotor of Gγ gene, which are -158C/T, -309A/G, -369C/G, and -567T/G. Also, four variations were observed in the 5’-UTR (untranslated regions) and promotor of Aγ gene, which are +25G/A, -369G/C, -499T/A, and -588G/A. One -222/-225 AGCA del homozygous and six variations as heterozygous in A gamma globin gene promotor region were also observed. The results of the current study suggested that there was a significant relationship between high HbF levels and two variations (-309A/T and -369C/G) in Gγ gene promotor. Additionally, a significant relationship between two variations (+25G/A and -499T/A) in Aγ gene promotor was also observed. Furthermore, the persons who carry these variations with high levels of HbF indicated that there might be a haplotype effect between these variations.</p>}, number={1}, journal={Cellular and Molecular Biology}, author={Aydin, Muhsin and Rencuzogullari, Eyyup and Dalyan, Ayse and Bayram, Suleyman and Genc, Ahmet}, year={2018}, month={Jan.}, pages={32–39} }