@article{Sohn_Kim_Hwang_Im_Moon_Kang_2012, title={TGF-β suppresses the expression of genes related to mitochondrial function in lung A549 cells}, volume={58}, url={https://www.cellmolbiol.org/index.php/CMB/article/view/562}, abstractNote={TGF-β is a mediator of lung fibrosis and regulates the alveolar epithelial type II cell phenotype. TGF-β can induce epithelial mesenchymal transition of idiopathic pulmonary disease and cancer metastasis. Peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1 α) is a key metabolic regulator that stimulates mitochondrial biogenesis and promotes remodeling of muscle tissue to oxidative fiber-type composition. Here, we report that the induction of TGF-β decreased mRNA expression of PGC-1α, and PGC-1 target genes, such as the transcription factors NRF-2, ERR-α, and PPAR-γ in lung epithelial A549 cells. In addition, TGF-β led to the reduction of super oxide dismutase 2 (anti-oxidant enzyme), cytochrome C (electron transport chain in mitochondria), and MCAD (a mitochondrial β-oxidant enzyme) in A549 cells. Together, our results suggest that TGF-β may suppress the transcriptional activity of the genes related to mitochondrial biogenesis or function. This mechanism may provide a novel insight into the understanding of fibrosis disease.}, number={2}, journal={Cellular and Molecular Biology}, author={Sohn, E. J. and Kim, J. and Hwang, Y. and Im, S. and Moon, Y. and Kang, D. M.}, year={2012}, month={Oct.}, pages={1763–67} }