@article{Bai_Zhao_Cao_Wen_Li_Meng_2012, title={Ghrelin promotion of oocyte maturation via ERK1/2 pathway in ovis aries}, volume={58}, url={https://www.cellmolbiol.org/index.php/CMB/article/view/567}, abstractNote={Ghrelin has recently garnered increasing attention in biomolecular studies. Ghrelin’s growth hormone secretagogue receptor type 1a (GHS-R) is a pleiotropic modulator of diverse biological functions, including energy homeostasis and reproduction. This study sought to understand the ways in which ghrelin impacts ERK1/2 and p90rsk during the ovis aries oocyte maturation process. We applied different concentrations of ghrelin and of ghrelin receptor inhibitor (D-Lys3-GHRP-6) to ovis aries oocytes and observed the effects on the ERK1/2 and p90rsk pathway. The ERK1/2 and p90rsk pathway plays an essential role in the in vitro maturation of ovis aries oocytes. This study discovered that ERK1/2 and p90 rsk pathway, during the ovis aries oocyte maturation, was associated with maturation of ovis aries oocyte in vitro.}, number={2}, journal={Cellular and Molecular Biology}, author={Bai, R. and Zhao, P. and Cao, G. and Wen, S. and Li, Q. and Meng, Q.}, year={2012}, month={Dec.}, pages={1797–02} }