TY - JOUR AU - Bai, R. AU - Zhao, P. AU - Cao, G. AU - Wen, S. AU - Li, Q. AU - Meng, Q. PY - 2012/12/05 Y2 - 2024/03/28 TI - Ghrelin promotion of oocyte maturation via ERK1/2 pathway in ovis aries JF - Cellular and Molecular Biology JA - Cell Mol Biol (Noisy-le-grand) VL - 58 IS - 2 SE - Original Research Articles DO - UR - https://www.cellmolbiol.org/index.php/CMB/article/view/567 SP - 1797-02 AB - Ghrelin has recently garnered increasing attention in biomolecular studies. Ghrelin's growth hormone secretagogue receptor type 1a (GHS-R) is a pleiotropic modulator of diverse biological functions, including energy homeostasis and reproduction. This study sought to understand the ways in which ghrelin impacts ERK1/2 and p90rsk during the ovis aries oocyte maturation process. We applied different concentrations of ghrelin and of ghrelin receptor inhibitor (D-Lys3-GHRP-6) to ovis aries oocytes and observed the effects on the ERK1/2 and p90rsk pathway. The ERK1/2 and p90rsk pathway plays an essential role in the in vitro maturation of ovis aries oocytes. This study discovered that ERK1/2 and p90 rsk pathway, during the ovis aries oocyte maturation, was associated with maturation of ovis aries oocyte in vitro. ER -