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Vol. 64 No. 9: Issue 9

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The roles of DNA epigenetics and clinical significance in Chronic Myeloid Leukemia: a review

https://doi.org/10.14715/cmb/2018.64.9.9
Aliasghar Keramatinia
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Alireza Ahadi
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mohammad Esmaeil Akbari
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Maryam Mohseny
Department of Social Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Alireza Mosavi Jarahi
Department of Social Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ayad Bahadori-Monfared
Department of Social Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mehrdad Hashemi
Department of Molecular Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
Afshin Moradi
Department of Pathology, Shohada Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran
Narjes Mehrvar
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Elham Kazemi
Department of Sexual Medicine, The Rhazes Center for Research in Family Health and Sexual Medicine; Kermanshah University of Medical Sciences, Kermanshah, Iran
Abolfazl Movafagh
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Corresponding Author(s) : Abolfazl Movafagh

movafagh_a@yahoo.com

Cellular and Molecular Biology, Vol. 64 No. 9: Issue 9

Abstract

Chronic Myeloid Leukemia (CML) is a myeloproliferative disorder characterized by the genetic translocation t(9;22) (q34;q11.2) encoding for the BCR-ABL fusion oncogene. Growing body of evidence suggests that epigenetic abnormalities are involved in tyrosine kinase resistance in CML, leading to leukemic clone escape and disease propagation. The significant of therapeutic role in chronic myeloid leukemia (CML) depends on both genetic and epigenetic mechanisms.  This article focused on the CML and epigenetic and clinical significance. An electronic search of peer-reviewed articles was systematically performed to obtain the relevant literature with the CINAHL, cancer, Google scholar, self-experience and PubMed databases. The keywords included leukemia, cancer, illness, epigenetic. The inclusion criteria for the reviews were that the documents were original quantitative research and published in English. Articles that were not directly relevant to the present objective were excluded. Current progress in molecular biology and bioinformatics offer novel promising experiments namely as next generation sequencing for new development in epigenetic figures characterization and more understanding of the epigenetic mechanisms to be successfully utilized for personalized CML therapy in the next coming years.

Keywords

Epigenetics CML Cancer Mechanisms MiRNAs.
Keramatinia, A., Ahadi, A., Akbari, M. E., Mohseny, M., Mosavi Jarahi, A., Bahadori-Monfared, A., Hashemi, M., Moradi, A., Mehrvar, N., Kazemi, E., & Movafagh, A. (2018). The roles of DNA epigenetics and clinical significance in Chronic Myeloid Leukemia: a review. Cellular and Molecular Biology, 64(9), 58–63. https://doi.org/10.14715/cmb/2018.64.9.9
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