Published: December 6, 2025

Original Research Articles

MiR-200b-3p is involved in colorectal cancer progression by targeting DDIT4

miR-200b-3p/DDIT4 Axis in colorectal cancer

1-7
Zhimin Liu, Yiping Li, Shangkui Xie , Donglin Ren, Dandan Huang

Xanthohumol suppresses ECM degradation in osteoarthritis through the Nrf2/ PERK/ATF4/C/EBPβ signaling pathway

Xanthohumol suppressed ECM degradation

20-30
Tiansheng Zheng, Shuo Niu, Qingluo Zhou, Jishang Huang, Jun Yi, Runhong Mei, Xuefeng Yu

Allele frequency of CTLA-4 rs231775 (+49 A>G) gene polymorphism and its association with cancer susceptibility in the Saudi Arabian population and other ethnic groups

CTLA-4 rs231775 and cancer susceptibility

31-37
Mohammad Salman Akhtar, Raed A. Alharbi, Arshi Talat, Abdulmajeed AA Sindi, Mohammad A. Shanawaz, Ali A Zaeri, Abdulbaset M Kabli, Abdulmohsen M Alruwetei, Dina K. Marghani

CircFOXK2 induces non-small cell lung cancer tumorigenesis through the miR-328-5p/PKP3 axis

CircFOXK2 promotes non-small cell lung cancer

38-44
Tongwei Xiang, Liping Chen, Huaying Wang, Tao Yu, Tang Li, Jipeng Li, Wanjun Yu

Glycation-mediated binding defect in human serum albumin transport of erdosteine: implications in diabetes

Erdosteine binding to human serum albumin in diabetes

45-52
Nada Mahmoud Dhab'an Al-Atawi, Ohud Mohammed Ahmad Al-Harbi, Rasha Sulaiman Muhammad Al-Finaikh, Sheakha Ahmad S Al-Blawi, Fahad M Almutairi, Rizwan Hasan Khan, Mohammad Rehan Ajmal

Shared gene functions in autoimmune diseases identified via integrated bioinformatics analysis

Shared gene functions in autoimmunity

53-60
Saniye Elvan Öztürk

Expression and significance of ALDH1A1, CD44, and OCT3/4 stem cell markers in glioblastoma tissues: an immunohistochemical study in Iraqi patients

Cancer stem cell markers expression in glioma

61-67
Zaynab S. Abdulghany, Noah A. Mahmood, Firas S. Salah, Karan Rana

Understanding the early onset of intracellular lipid accumulation induced by oleic and palmitic acids in HepG2 cells

Early lipid accumulation in HepG2 cells

68-73
Esther Jebarani Elangovan, Rihana Habeeb Rakuman, Adaikkalam Vellaichamy

Skin regenerative potential of polydeoxyribonucleotide isolated from Saussurea involucrata

Snow lotus PDRN for skin regeneration

94-99
Da Jung Kim, Sun-Uk Bak, Seung Youn Lee, Min Sook Jung, Hee Un Jin, Chae Eun An

Vaccination and vitamin D in relation to disease severity and mortality in patients with COVID-19 disease: a follow-up study

COVID-19 status, its Vaccination, and vitamin D

100-108
Aleen Sardar Al-noori, Ahmed Mohamed Salih, Muayad Aghali Merza

Tirzepatide alters oncogenic signaling pathways in colorectal cancer cells in vitro

Tirzepatide effects on colorectal cancer cells

119-124
Nasrin M. Fadhil, Jawad Hasan Kadhim, Hatham W. Atwan, Huda A. Alwan, Zeenah W. Atwan

Reviews

Update on glycogen storage disease: a brief review of the main disorders

GSD update

8-19
Ayed A. Dera, Mesfer Al Shahrani, Gaffar Sarwar Zaman, Ahmad Mohammed Asiri, Abdullah Alasmari, Lana Alqhtani, Abeer Alghamdi, Amal Alzahrani, Abdulrhman Khalofa Alasmari

Molecular and cellular biomarkers in Crohn’s disease: from pathogenesis to clinical application

Molecular biomarkers of Crohn’s disease

109-118
Alexander Blagov, Marina D. Sazonova, Anastasia I. Ryzhkova , Vasily P. Karagodin, Mikhail A. Popov , Egor Yu. Budnikov , Elizaveta R. Korchagina, Alexander N. Orekhov, Margarita A. Sazonova, Yuri V. Arkhipenko

Meta-Analysis

Hepatitis B reactivation linked to tumor necrosis factor-α inhibitors in rheumatoid arthritis: a systematic review and meta-analysis

HBV reactivation with TNF-α inhibitors in RA

74-85
Pouria ‎ Salajegheh ‎, Farzaneh Yazdi, Amirali ‎ Salajegheh ‎

Case Report

Combined intrathecal and intravenous exosome injection efficiency in a multiple sclerosis patient: a case report

Intrathecal and IV exosomes in MS: case report

Azam Mohammad Jafari, Kambiz Sadegi ‎, Mania Kaveh ‎, Yasaman Zandi Mehran ‎, Michael ‎ Weber ‎, Seyed Ali Golestanha ‎, Fateme Hoseinzade ‎, Nahid Tafazoli Harandi ‎, Mozhgan Ayazi ‎, Hans Michael Weber