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Vol. 64 No. 5: Issue 5

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Comparison of serum levels of IL-6, IL-8, TGF-β and TNF-α in coronary artery diseases, stable angina and participants with normal coronary artery

https://doi.org/10.14715/cmb/2018.64.5.1
Zahra Sepehri Sepehri
Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran
Mohammad Masoomi
Cardiovascular Research Center, Institute of Basic and Clinical "ŽPhysiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
Fatemeh Ruzbehi
Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
Zohreh Kiani
Department of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Ali Akbar Nasiri
Department of Internal Anesthesiology, Zabol University of Medical Sciences, Zabol, Iran
Farhad Kohan
Zabol University of Medical Sciences, Zabol, Iran
Mahmood Sheikh Fathollahi
Faculty of Medicine, and Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Mohammad Kazemi Arababadi
Faculty of Paramedicine and Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Derek Kennedy
School of Natural Sciences, Eskitis Institute for Drug Discovery, Griffith University Nathan, Queensland, Australia
Gholamreza Asadikaram Asadikaram
Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Corresponding Author(s) : Mohammad Masoomi

mohammadmasoomi@yahoo.com

Cellular and Molecular Biology, Vol. 64 No. 5: Issue 5

Abstract

Cytokines, which typically regulate the immune responses, play a role in cardiovascular diseases such as coronary artery diseases (CAD) and ischemic heart diseases (IHD). The aims of this study were to evaluate serum levels of IL-6, IL-8, TGF-β and TNF-α in patients with or without CAD, as well as stable angina, and to assess the effects of drug administration on the serum levels of these cytokines. Serum levels of the cytokines were analyzed in the three groups: patients with acute coronary syndrome, stable angina and participants with normal coronary arteries as controls. Cohort study of the patients showed that Nitrocontin was the only drug used in a significantly different pattern between the groups where it was used less frequently in patients with stable angina compared to the acute coronary syndrome or control groups. Serum levels of the evaluated cytokines were not different neither between the studied groups nor between the groups with variable Gensini scores. However, IL-8 in controls that were not engaged in regular exercise was higher than the controls performing regular exercise. In the stable angina group, TNF-α in non-smokers was higher than the smokers. It was revealed that serum levels of pro-inflammatory cytokines are not associated with atherosclerosis and stable angina in patients from the South-East of Iran. However, suppressed expression of TGF-β, may increase the risk of CAD. Exercise can reduce the risk of CAD through downregulation of pro-inflammatory cytokines.

Keywords

Cytokine Stable angina Arthrosclerosis.
Sepehri, Z. S., Masoomi, M., Ruzbehi, F., Kiani, Z., Nasiri, A. A., Kohan, F., Sheikh Fathollahi, M., Kazemi Arababadi, M., Kennedy, D., & Asadikaram, G. A. (2018). Comparison of serum levels of IL-6, IL-8, TGF-β and TNF-α in coronary artery diseases, stable angina and participants with normal coronary artery. Cellular and Molecular Biology, 64(5), 1–6. https://doi.org/10.14715/cmb/2018.64.5.1
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