Ghrelin promotion of oocyte maturation via ERK1/2 pathway in ovis aries
Corresponding Author(s) : G. Cao
Cellular and Molecular Biology,
Vol. 58 No. 2: General Papers
Ghrelin has recently garnered increasing attention in biomolecular studies. Ghrelin's growth hormone secretagogue receptor type 1a (GHS-R) is a pleiotropic modulator of diverse biological functions, including energy homeostasis and reproduction. This study sought to understand the ways in which ghrelin impacts ERK1/2 and p90rsk during the ovis aries oocyte maturation process. We applied different concentrations of ghrelin and of ghrelin receptor inhibitor (D-Lys3-GHRP-6) to ovis aries oocytes and observed the effects on the ERK1/2 and p90rsk pathway. The ERK1/2 and p90rsk pathway plays an essential role in the in vitro maturation of ovis aries oocytes. This study discovered that ERK1/2 and p90 rsk pathway, during the ovis aries oocyte maturation, was associated with maturation of ovis aries oocyte in vitro.
Ghrelin Oocyte maturation ERK1/2.
Bai, R., Zhao, P., Cao, G., Wen, S., Li, Q., & Meng, Q. (2012). Ghrelin promotion of oocyte maturation via ERK1/2 pathway in ovis aries. Cellular and Molecular Biology, 58(2), 1797–02. Retrieved from https://www.cellmolbiol.org/index.php/CMB/article/view/567
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