The cytotoxic activity of Ziziphus Jujube on cervical cancer cells: In Vitro study
Cellular and Molecular Biology,
Vol. 61 No. 8: Issue 8
Recently, there are tendency to use natural products such as Ziziphus Jujube (Jujube) as therapeutic agents for cancer. Understanding the molecular mechanisms of anti-cancer effects of Jujube may improve the current therapeutic strategies against cervical cancer. Our MTT data showed a significant dose- and time-dependent inhibition of OV-2008 cell proliferation following Jujube administration. Moreover, qRT-PCR analyses significantly revealed the suppression of cyclin D1 and the enhancement of P53, P21 and P27 expression in treated cells. These results suggest that the herb exerts a cytotoxic effect on cervical cancer cells through alternation of the expression of the genes that are involved in regulation of cell cycle.
Hoshyar, R., Jamali, S., Fereidouni, M., & Abedini, M. R. (2015). The cytotoxic activity of Ziziphus Jujube on cervical cancer cells: In Vitro study. Cellular and Molecular Biology, 61(8), 128–130. Retrieved from https://www.cellmolbiol.org/index.php/CMB/article/view/770
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