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Vol. 62 No. 3: Issue 3

Human colon cancer HT-29 cell death responses to doxorubicin and Morus Alba leaves flavonoid extract

S Fallah
Iran University of Medical Sciences Department of Biochemistry, Faculty of Medicine Tehran Iran
A Karimi
Tehran University of Medical Sciences Department of Biochemistry Tehran Iran
G Panahi
Tehran University of Medical Sciences Department of Biochemistry Tehran Iran
S Gerayesh Nejad
Tehran University of Medical Sciences Department of Biochemistry Tehran Iran
R Fadaei
Iran University of Medical Sciences Department of Biochemistry, Faculty of Medicine Tehran Iran
M Seifi
University of Alberta Department of Medical Genetics, Faculty of Medicine and Dentistry Edmonton Canada

Corresponding Author(s) : S Fallah

fallah.s@iums.ac.ir

Cellular and Molecular Biology, Vol. 62 No. 3: Issue 3

Abstract

The mechanistic basis for the biological properties of Morus alba flavonoid extract (MFE) and chemotherapy drug of doxorubicin on human colon cancer HT-29 cell line death are unknown. The effect of doxorubicin and flavonoid extract on colon cancer HT-29 cell line death and identification of APC gene expression and PARP concentration of HT-29 cell line were investigated. The results showed that flavonoid extract and doxorubicin induce a dose dependent cell death in HT-29 cell line. MFE and doxorubicin exert a cytotoxic effect on human colon cancer HT-29 cell line by probably promoting or induction of apoptosis.

Keywords

Cell death Doxorubicin Flavonoid Viability.
Fallah, S., Karimi, A., Panahi, G., Gerayesh Nejad, S., Fadaei, R., & Seifi, M. (2016). Human colon cancer HT-29 cell death responses to doxorubicin and Morus Alba leaves flavonoid extract. Cellular and Molecular Biology, 62(3), 72–77. Retrieved from https://www.cellmolbiol.org/index.php/CMB/article/view/822
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